sno-lncRNAs: a story of splicing across humans, rhesus and mice

Thursday, 17 April, 2014

Convention tells us that ‘DNA makes RNA makes protein’, but the function of the majority of RNA that does not code for protein has, historically, been less clear. The recent advent of high-throughput sequencing technology has challenged our preconceptions of long non-coding RNA (lncRNA) and revealed it to be one of the most abundant RNA molecules. Although only a small number of lncRNAs have been well characterised, they appear to be crucial in the control of gene expression pathways and are no longer considered ‘transcriptional noise’.